Sulforaphane - What you should know!
Broccoli vs. Cancer Studies and Clinical Trials
Pharmacokinetic studies in both rats and humans demonstrated that sulforaphane can be distributed in the body and reach micromolar concentrations in the blood. Broccoli sprouts contain up to 50 times higher concentrations of the sulforaphane precursor glucoraphanin than mature broccoli, which make sprouts the better candidates for clinical trials.
Of the phytochemicals with Nrf2 inducer capacity, Brassica-derived SFN is the most potent naturally occurring biomolecule known at this time. It is not only a potent Nrf2 inducer but also highly bioavailable so that modest practical doses can produce significant clinical responses. The daily SFN dose found to achieve beneficial outcomes in most of the available clinical trials is around 20-40 mg. With a potent, myrosinase-active whole broccoli sprout supplement, these doses can be attained with just a few capsules daily.
Sulforaphane is an anti-cancer compound in cruciferous vegetables, mostly commonly credited to Broccoli. It appears to have general but potent antioxidant and possible anti-inflammatory actions, with the former similar to curcumin. Sulforaphane is a small category in herbal extract industry, also the development of the market is mainly in the past 20 years.
SFN has roles in cancer prevention, high blood pressure, macular degeneration and stomach ulcers and is a potent inducer of mammalian phase II detoxication enzyme systems which deactivate and excrete many carcinogens.
Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells
Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study
Sulforaphane: Benefits, Side Effects, and Food Sources
The Glucosinolates: A Sulphur Glucoside Family of Mustard Anti-Tumour and Antimicrobial Phytochemicals of Potential Therapeutic Application
Sulforaphane: Its "Coming of Age" as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease
Isothiocyanate from Broccoli, Sulforaphane, and Its Properties
Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
Broccoli Microgreens: A Mineral-Rich Crop That Can Diversify Food Systems