The p53 gene is central to the study of cancer prevention and treatment.  More than 50% of adult cancers have a broken p53 gene. 

SFN has been shown to protect the p53 gene from degradation or damage. 

This indicates a potential key role for SFN in helping to prevent a wide range of cancers.


Clarke JD, Dashwood RH, Ho E. Multi-targeted prevention of cancer by sulforaphane. Cancer Lett. 2008 Oct 8;269(2):291-304. doi: 10.1016/j.canlet.2008.04.018. Epub 2008 May 27. PMID: 18504070; PMCID: PMC2579766.

Asher G, Lotem J, Sachs L, Kahana C, Shaul Y. Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13125-30. doi: 10.1073/pnas.202480499. Epub 2002 Sep 13. PMID: 12232053; PMCID: PMC130597.

Role of Nrf2 and NQO1 in the attenuation of oxygen-mediated pulmonary toxicity by sulforaphane. Renjithkumar Kalikkot Thekkeveedu, Chun Chu, Bhagavatula Moorthy Pediatrics May 2018, 142 (1 MeetingAbstract) 178; DOI: 10.1542/peds.142.1_MeetingAbstract.178

Soussi T, Wiman KG. Shaping genetic alterations in human cancer: the p53 mutation paradigm. Cancer Cell. 2007 Oct;12(4):303-12. doi: 10.1016/j.ccr.2007.10.001. PMID: 17936556.

Asher G, Lotem J, Kama R, Sachs L, Shaul Y. NQO1 stabilizes p53 through a distinct pathway. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3099-104. doi: 10.1073/pnas.052706799. Epub 2002 Feb 26. PMID: 11867746; PMCID: PMC122479.