SULFORAPHANE HELPS MAINTAIN A HEALTHY BRAIN

In animal studies, SFN has been shown to increase BDNF (brain derived neurotropic factor), which protects existing brain cells and promotes the growth of new ones—as well as increased connectivity among brain cells. 

Multiple animal studies have shown that SFN can protect against diseases like Alzheimer’s, Parkinson’s, depression and schizophrenia. 

Human studies validating these results have not yet been completed.

 

Kim J, Lee S, Choi BR, Yang H, Hwang Y, Park JH, LaFerla FM, Han JS, Lee KW, Kim J. Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways. Mol Nutr Food Res. 2017 Feb;61(2). doi: 10.1002/mnfr.201600194. Epub 2016 Nov 30. PMID: 27735126.

Zhang J, Zhang R, Zhan Z, Li X, Zhou F, Xing A, Jiang C, Chen Y, An L. Beneficial Effects of Sulforaphane Treatment in Alzheimer's Disease May Be Mediated through Reduced HDAC1/3 and Increased P75NTR Expression. Front Aging Neurosci. 2017 May 1;9:121. doi: 10.3389/fnagi.2017.00121. PMID: 28507518; PMCID: PMC5410605.

Klomparens EA, Ding Y. The neuroprotective mechanisms and effects of sulforaphane. Brain Circ. 2019 Apr-Jun;5(2):74-83. doi: 10.4103/bc.bc_7_19. Epub 2019 Jun 27. PMID: 31334360; PMCID: PMC6611193.

Morroni F, Tarozzi A, Sita G, Bolondi C, Zolezzi Moraga JM, Cantelli-Forti G, Hrelia P. Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease. Neurotoxicology. 2013 May;36:63-71. doi: 10.1016/j.neuro.2013.03.004. Epub 2013 Mar 18. PMID: 23518299.

Zhang JC, Yao W, Dong C, Yang C, Ren Q, Ma M, Han M, Wu J, Ushida Y, Suganuma H, Hashimoto K. Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation. J Nutr Biochem. 2017 Jan;39:134-144. doi: 10.1016/j.jnutbio.2016.10.004. Epub 2016 Oct 11. Erratum in: J Nutr Biochem. 2020 Nov 23;88:108550. Erratum in: J Nutr Biochem. 2020 Dec 17;89:108562. PMID: 27833054.

Wu S, Gao Q, Zhao P, Gao Y, Xi Y, Wang X, Liang Y, Shi H, Ma Y. Sulforaphane produces antidepressant- and anxiolytic-like effects in adult mice. Behav Brain Res. 2016 Mar 15;301:55-62. doi: 10.1016/j.bbr.2015.12.030. Epub 2015 Dec 22. PMID: 26721468.

Shiina A, Kanahara N, Sasaki T, Oda Y, Hashimoto T, Hasegawa T, Yoshida T, Iyo M, Hashimoto K. An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients with Schizophrenia. Clin Psychopharmacol Neurosci. 2015 Apr 30;13(1):62-7. doi: 10.9758/cpn.2015.13.1.62. PMID: 25912539; PMCID: PMC4423155.